HUN-REN BRC CF.

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Metabolomics

About us

Metabolomics is the systematic study of metabolite level changes. Among the molecular omics (such as genomics, transcriptomics and proteomics) metabolite levels are the closest to the phenotype of organisms. Metabolite level changes may affect intra- and extracellular communication, stress responses or could indicate non-metabolic changes as well.
Our goal is to bring metabolomics closer to your research and expand the scope of your studies.

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Technology

Sample types

Sample types we have expertise:
Bacterial cell culture, mammalian cell culture, plant leaf, yeast cell culture, urine, algae, Blood plasma/serum, nodules, C. elegans, human tissues and many others.
We are ready to measure metabolites from any new and challenging types of biological materials.

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Services

Our untargeted metabolomics method is applicable to various sample types from plants to mammalian cell cultures also. The method covers metabolic pathways from central carbon metabolism to amino acids and their biosynthesis. It provides semi-quantitative data about ~160 metabolites with outstanding cost-effectiveness. The data analysis utilizes organism-specific metabolic network reconstructions as well; therefore datasets are suitable for metabolic pathway-level systematic analysis. In order to extend the coverage of our untargeted metabolomics methods, we are applying compound class specific methods in high throughput fashion. These methods cover energy metabolism and nucleotide phophates, TCA cycle, and amino acids.

Untargeted Metabolomics

Our pipeline focuses on the comprehensive analysis of the polar metabolome and employs two measurement modes, supported by a metabolite library containing over 500 endogenous metabolites. This method provides semiquantitative data on the metabolome, making it well-suited for system-level omics studies.
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Targeted TCA cycle metabolite level determination

Measuring metabolites in the TCA (tricarboxylic acid) cycle is crucial for understanding cellular energy production and metabolic regulation, as it is a central pathway in aerobic respiration. Additionally, alterations in TCA cycle metabolites are often associated with the metabolic reprogramming of cancer cells, as this pathway is critical for supporting the rapid proliferation and survival of tumors through enhanced energy production and biosynthesis.
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Targeted amino acid level determination

Determining amino acid levels is essential for understanding protein synthesis, metabolic health, and, as amino acids serve as the building blocks for proteins and are involved in numerous cellular processes. Additionally, alterations in amino acid concentrations can signal metabolic disorders, and abiotic stress states in various model systems.
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Energy metabolism and nucleotide phosphates

Nucleotide phosphates, such as ATP, GTP, and their derivatives, along with electron carriers like NADH and NADPH, are essential for fuel biochemical reactions, maintain homeostasis and redox reactions. Those metabolites playing key roles in cellular respiration, and the regulation of oxidative stress reactions.
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University of Szeged
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Eötvös Loránd University
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Articles

Key publications

Team

Check our Team

Roland TENGÖLICS

Research Associate

Csilla SAJBEN

Research Assistant